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Angiotensin-Converting Enzyme Gene Polymorphisms and Tissue Oxygenation During Exercise: Conclusion

Angiotensin-Converting Enzyme Gene Polymorphisms and Tissue Oxygenation During Exercise: ConclusionHighly inefficient muscles would tend to utilize more oxygen at any level of exercise, and are more likely to cross anaerobic threshold early. Recently, the possibility that ACE may play a role in muscle deconditioning and weakness has been suggested in cardiac patients. However, further research will be required to clarify this issue. More info buy antibiotics online
There are several additional possible explanations for the observed association between ACE polymorphisms and disturbance in tissue oxygenation during exercise in COPD patients. Population stratification based on ethnicity or other factors could have contributed to disturbance in tissue oxygenation across genotypes. However, all of the subjects in this study were Japanese, so population stratification is less likely. In addition, it is also possible that the deletion polymorphism is associated with tissue oxygenation because this polymorphism is linkage disequilibrium with another causative variant in or near the ACE gene.
In conclusion, though this study had limited sample size, the ACE DD genotype might be associated with disturbance in peripheral tissue oxygenation during exercise in patients with COPD. Further studies are needed to determine whether improved tissue oxygenation with exercise after ACE inhibitors or angiotensin II receptor antagonists is associated with ACE genotype-based variation in response to these therapy in patients with COPD.