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Angiotensin-Converting Enzyme Gene Polymorphisms and Tissue Oxygenation During Exercise: COPD

Pvo2 during exercise reflects the adequacy of oxygen transport to the peripheral tissues and, thus, the state of tissue oxygenation. In this study, we found that Pvo2 after exercise was significantly lower in patients with the DD genotype than in those with the II and ID genotypes. Moreover, ALactate was also significantly higher in patients with the DD genotype than in those with the II and ID genotypes, It therefore seems likely that the ACE DD genotype is associated with the disturbance of tissue oxygenation. Local distribution of blood flow to exercising muscles, the partial pressure gradient for oxygen diffusion into tissues, the distance of diffusion to mitochondria, and the capacity of the oxygen utilization process could all theoretically affect tissue oxygenation. Interestingly, we found that the mean PAP after exercise was not significantly correlated with Pvo2 after exercise and with ALactate. canadian neighbor pharmacy
Since tissue oxygenation depends on both the convective and diffusional oxygen transport processes, it is possible that ACE polymorphisms are associated with the disturbance not only of convective oxygen transport, but also of diffusional oxygen transport. The explanation of these findings would suggest the following mechanisms. One mechanism is that the muscle oxygen needs in patients with the DD genotype is significantly greater at any level of exercise than for patients with the II and ID genotypes. Thus, decreased levels of Do2 for patients with the DD genotypes would result in a relative oxygen deficit for these patients requiring additional oxygen extraction and allowing the development of some larger degree of anaerobiosis. Another mechanism is selective muscle dysfunction with decreased peripheral muscle aerobic efficiency in patients with the DD genotype.