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Category: COPD

Risk and Severity of COPD Is Associated With the Group-Specific Component of Serum Globulin 1F Allele: Conclusion

There are several limitations in our study. First, the age and smoking history in pack-years of the control group were not exactly equivalent to the COPD patient group. Considering that some sub jects in the control group might subsequently acquire Read More

Risk and Severity of COPD Is Associated With the Group-Specific Component of Serum Globulin 1F Allele: FEV1/FVC

Previous studies have shown that LAA% and sCLA correlated well with FEV1 percentage predicted and FEV1/FVC. In HRCT examinations, patients with Gc*1F allele had a higher LAA%, lower mean CT score, and larger sCLA than patients without the allele, whereas Read More

Risk and Severity of COPD Is Associated With the Group-Specific Component of Serum Globulin 1F Allele:

They concluded that the reason was due to the insufficient number of subjects needed to verify the hypothesis that Gc*1F homozygotes had an increased risk. These studies were based on white populations in which the frequencies of the three alleles Read More

Risk and Severity of COPD Is Associated With the Group-Specific Component of Serum Globulin 1F Allele: Discussion

Simple linear regression analysis was used for studying correlations between LAA% and mean CT score. Mean CT score was linearly correlated with LAA% (R2 = 0.97, p < 0.001), with a simple linear regression model as follows: mean CT score Read More

Risk and Severity of COPD Is Associated With the Group-Specific Component of Serum Globulin 1F Allele: dFEV1

Follow-up pulmonary function data for calculating dFEV1 was available in 86 of the 103 patients with COPD, and 21 of the 88 smoker control subjects, There was no significant difference in age, smoking history, the baseline FEV1 percentage predicted, and Read More

Risk and Severity of COPD Is Associated With the Group-Specific Component of Serum Globulin 1F Allele: Pulmonary Function Testing

Pulmonary function tests were performed at the initial visit, and at each of the follow-up visits. The initial test values were used as the baseline data. When follow-up data were available > 1 year after the initial test, dFEV1 was Read More

Risk and Severity of COPD Is Associated With the Group-Specific Component of Serum Globulin 1F Allele: Statistical Analysis

To test Gc-globulin phenotypic variance between patients with COPD and healthy smokers, and to compare the frequency of individuals over or under the threshold (dFEV1 > 90 mL/yr, LAA% > 60%, or mean CT score < — 940 HU) in Read More

Risk and Severity of COPD Is Associated With the Group-Specific Component of Serum Globulin 1F Allele: Genotyping

DNA for genotyping was extracted from blood using standard phenolchloroform method. To detect point mutations in exon XI (Glu/Asp 416 and Thr/Lys 420) of the Gc-globulin gene, polymerase chain reaction (PCR) was performed followed by restriction fragment-length polymorphism analysis. To Read More

Risk and Severity of COPD Is Associated With the Group-Specific Component of Serum Globulin 1F Allele: Materials and Methods

We also considered it important to test the contribution of Gc-globulin genotypes to the disease progression or severity in patients with COPD because, to our knowledge, this has not yet been investigated. The annual decline of FEV1 (dFEV1) is often Read More

Risk and Severity of COPD Is Associated With the Group-Specific Component of Serum Globulin 1F Allele

Although the most critical factor for acquiring COPD is cigarette smoking, only 15 to 20% of chronic smokers get this disease. Several epidemiologic studies have suggested familial clustering of the disease. This suggests that the genetic factors are likely to Read More

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