Category Archives: Protein

Extended Evaluation of Recombinant Human Activated Protein C United States Trial

Extended Evaluation of Recombinant Human Activated Protein C United States TrialSevere sepsis, a generalized inflammatory host ^ response to infection that results in coagulopathy, diffuse endovascular injury, and death, occurs in approximately 750,000 patients in the United States each year. Patients with severe sepsis often experience failures of multiple organ systems, and recent estimates suggest that between 36% and 60% of all cases are fatal. Despite technical advances in critical care, including new dialysis techniques and methods of mechanical ventilation, sophisticated nutritional support, and antimicrobial therapies, mortality from severe sepsis and its sequelae had remained largely unchanged until the recombinant human activated Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) trial.