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Category: Pulmonary

Feasibility of Routine Pulmonary Arterial Impedance Measurements in Pulmonary Hypertension: Right Heart Catheterization

Right heart catheterization was performed without premedication, with the patient lying supine and breathing room air. A balloon-tipped, flow-directed thermodilution 7F Swan-Ganz catheter (131HF7; Baxter Healthcare Corp; Irvine, CA) was inserted under local anesthesia into an internal jugular vein and Read More

Feasibility of Routine Pulmonary Arterial Impedance Measurements in Pulmonary Hypertension: Materials and Methods

There are only a few previous studies, on PVZ in PAH patients. This is to be explained by the technical difficulties of instantaneous pressure and flow measurements requiring high-fidelity, manometer-tipped catheters and flowmeters. It has been generally assumed that the Read More

Feasibility of Routine Pulmonary Arterial Impedance Measurements in Pulmonary Hypertension

Right heart catheterization with measurements of pulmonary vascular pressures and cardiac output, and the calculation of pulmonary vascular resistance (PVR) is an essential step in the diagnosis of pulmonary arterial hypertension (PAH). These hemodynamic measurements are of prognostic value, with, Read More

Identification of Spontaneous Feline Idiopathic Pulmonary Fibrosis: Summary

An abnormality in alveolar repair would also preclude the necessity of continued superimposed inflammation to drive alveolar remodeling; the lack of an essential role for inflammation in the pathogenesis has been proposed by Selman et al. The ultrastructural findings in Read More

Identification of Spontaneous Feline Idiopathic Pulmonary Fibrosis: Human disease

The distribution of myofibroblasts in feline IPF are similar to that of the human disease. While myofibroblasts are found in rodent models of pulmonary fibrosis, because of the lack of honeycombing, they lack the relationship with the metaplastic epithelium that Read More

Identification of Spontaneous Feline Idiopathic Pulmonary Fibrosis: UIP changes

Cats with IPF acquire lung histopathology similar to human IPF. Previous to the 2000 statement designating UIP as the pathologic manifestation of IPF, acute interstitial pneumonia, desquamative interstitial pneumonia, and NSIP were also considered variations of IPF. These other pulmonary Read More

Identification of Spontaneous Feline Idiopathic Pulmonary Fibrosis: Human IPF

This study describes spontaneous feline IPF, a newly identified chronic lung disease of domestic cats that shares critical features with human IPF. The important gross pathology, histopa-thology, cell differentiation markers, and ultrastruc-tural features are compared to the well-described features of Read More

Identification of Spontaneous Feline Idiopathic Pulmonary Fibrosis: Discussion

Ultrastructure: In the toluidine blue-stained, plastic-embedded lung prepared for electron microscopy, the interstitium of the pulmonary parenchyma was markedly thickened with abundant collagen. In the areas of type II pneumocyte hyperplasia and differentiation, the individual pneumocytes contained many cytoplasmic, variably Read More

Identification of Spontaneous Feline Idiopathic Pulmonary Fibrosis: Lung

Fibroblast foci, small foci of ongoing mesenchymal cell proliferation with fibroblasts/myofibroblasts and collagen, similar to the foci seen in UIP of humans were observed at the periphery of the honeycomb lung (Fig 3, top left, A [human], and top right, Read More

Identification of Spontaneous Feline Idiopathic Pulmonary Fibrosis: Necropsy Findings

Grossly, the distribution of lesions involved large regions of the lungs. The pleural surface of the lungs was often irregular and cobblestoned in appearance (Fig 1, top, A). The areas of fibrosis and remodeling formed plaque-like depositions that were discrete Read More

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