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Category: Pulmonary

Identification of Spontaneous Feline Idiopathic Pulmonary Fibrosis: Immunohistochemistry

Electron Microscopy: Tissues from three affected cats were prepared for electron microscopy. The samples were rinsed in 0.1 mol/L phosphate buffer and placed in osmium tetroxide (Electron Microscopy Sciences; Fort Washington, PA) for 3 h. The tissues were then rerinsed Read More

Identification of Spontaneous Feline Idiopathic Pulmonary Fibrosis: Materials and Methods

We report herein a novel spontaneous chronic, progressive respiratory disease in domestic cats with the morphologic features of UIP; these features include the temporal heterogeneity, persistent, progressive proliferation of myofibroblasts/fibroblasts, and an association between IPF and the development of primary Read More

Identification of Spontaneous Feline Idiopathic Pulmonary Fibrosis: IPF

Animal models currently used to study IPF do not appropriately mimic the morphologic changes of IPF. As stated in the National Heart, Lung, and Blood Institute workshop summary,2 persistent progressive fibrosis with evidence of temporal heterogeneity is a hallmark of Read More

Identification of Spontaneous Feline Idiopathic Pulmonary Fibrosis

Idiopathic pulmonary fibrosis (IPF), also known as cryptogenic fibrosing alveolitis, is a poorly understood respiratory disease of humans. Affecting approximately 11 male and 8 female patients, respectively, per 100,000 individuals per year, it is one of the more prevalent interstitial Read More

The Overlap Between Respiratory Bronchiolitis and Desquamative Interstitial Pneumonia: Conclusion

Our study suggests that in some individuals with PLCH, extensive RB/ DIP-like changes may be the lesion responsible for the majority of physiologic and clinical abnormalities, rather than the lesions of PLCH. Irrespective of how one defines the final pathologic Read More

The Overlap Between Respiratory Bronchiolitis and Desquamative Interstitial Pneumonia: PLCH biopsy specimens

Whereas RB is an extremely common lesion that refers to the universal inflammatory reaction found in the respiratory bronchioles of cigarette smokers, RB-ILD is an uncommon ILD that occurs in a small proportion of smokers. In analogy to DIP, the Read More

The Overlap Between Respiratory Bronchiolitis and Desquamative Interstitial Pneumonia: Discussion

No correlation was found between the degree of RB/DIP-like changes and pulmonary function parameters, including TLC (r = — 0.22, p = 0.45), Dlco (r = — 0.42, p = 0.13), or FEV1 (r = 0.11, p = 0.71). Although Read More

The Overlap Between Respiratory Bronchiolitis and Desquamative Interstitial Pneumonia: Radiographic

Cystic change was identified as the sole HRCT abnormality in three cases. Ground-glass attenuation was detected on HRCT in three patients (Table 2). Emphysema was detected in two cases on HRCT (14%). Mild sub-carinal and pretracheal adenopathy (1 to 2 Read More

The Overlap Between Respiratory Bronchiolitis and Desquamative Interstitial Pneumonia: Clinical and Radiographic Characteristics

The second patient (patient 2 in Tables 1, 2) was a 48-year-old white man with a 30-pack-year smoking history referred for evaluation of progressive dyspnea. Although claiming to have quit smoking several months prior to evaluation, arterial blood gas analysis Read More

The Overlap Between Respiratory Bronchiolitis and Desquamative Interstitial Pneumonia: Results Summary of the Two Index Cases

Correlations between the extent of RB/DIP-like changes (0 to 100% involvement of biopsy) and total pack-years smoked was performed using linear regression analysis and the Pearson correlation coefficient. Similarly, correlations between the extent of RB/DIP-like changes and pulmonary function variables Read More

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