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Category: Pulmonary

Prognosis of Patients With Advanced Idiopathic Pulmonary Fibrosis Requiring Mechanical Ventilation for Acute Respiratory Failure

Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing inflammatory lung disease of unknown etiology. The prognosis of the disease is particularly severe, with a mean length of survival after diagnosis ranging from 3 to 5 years. This poor prognosis is Read More

Iatrogenic Paradoxical Air Embolism in Pulmonary Hypertension: Discussion

This report describes four cases of PH-associated PAE encountered at our institution over the past 5 years. Two patients experienced PAE via a PFO during a diagnostic ASCE. Two additional patients with ES were being treated with continuous IV epoprostenol Read More

Iatrogenic Paradoxical Air Embolism in Pulmonary Hypertension: Case Reports3,4

Case 3 A 44-year-old white man with a history of idiopathic pulmonary fibrosis and chronic atrial fibrillation presented to our institution with worsening dyspnea and hypoxia, thought to be due to progressive fibrosis, and subsequently underwent pretransplantation evaluation. He was Read More

Iatrogenic Paradoxical Air Embolism in Pulmonary Hypertension: Case Reports

Case 1 A 44-year-old white woman with long-standing ES associated with a secundum atrial septal defect (ASD) presented to Vanderbilt Medical Center in June, 1999 with progressive dyspnea and weakness (Table 1) and worsening PH. IV epoprostenol therapy had recently Read More

Iatrogenic Paradoxical Air Embolism in Pulmonary Hypertension

Paradoxical systemic air embolism (PAE) is defined as an arterial air embolus originating from a venous source passing through an intracardiac or intrapulmonary right-to-left shunt. The phenomenon may result in a significant embolic event, such as a cerebrovascular accident or Read More

Usefulness of Pulmonary Vascular Leakiness Assessment in Interstitial Pneumonitis: Discussion

Symptoms and chest radiograph findings are suitable clinical indicators of IP activity, though their precise quantification is difficult. Serum lactate dehydrogenase may also be a rough indicator of disease activity in conditions unassociated with other organ dysfunctions, including liver disease. Read More

Usefulness of Pulmonary Vascular Leakiness Assessment in Interstitial Pneumonitis: Results

The LI in patients with IP was significantly higher than in the control group, while no significant difference in gallium index was found between the control and the IP group (Fig 3). No significant correlation was observed between gallium index Read More

Usefulness of Pulmonary Vascular Leakiness Assessment in Interstitial Pneumonitis: Estimation of LI

Using the dynamic scanning data, pulmonary vascular leakiness was assessed by LI, which is the exponential equilibration coefficient of Ga-circulating transferrin between the intravas-cular and pulmonary interstitial compartments. Our deliberate choice of Ga as a leak marker, instead of mIn-transferrin Read More

Usefulness of Pulmonary Vascular Leakiness Assessment in Interstitial Pneumonitis

Inflammatory alteration in the function of the barrier of the alveolar septum is one of the main pathophysiologic events leading to destruction of the pulmonary architecture and to pulmonary fibrosis. Increased pulmonary epithelial permeability following alveolar septal injury has been Read More

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