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Category: Reproductive Axis

Leptin’s Actions on the Reproductive Axis: MECHANISMS OF LEPTIN’S ACTIONS ON REPRODUCTION(5)

Thus the potential exists for leptin to influence reproductive function during fasting through altering the availability of POMC gene products. Indeed, the endogenous opioid p-endorphin as well as a-melanocyte-stimulating hormone (a-MSH) have been implicated in modulating both feeding and reproduction. Read More

Leptin’s Actions on the Reproductive Axis: MECHANISMS OF LEPTIN’S ACTIONS ON REPRODUCTION(4)

Other substances may be intermediaries in the signal transduction pathway between leptin and GnRH release. Neurons containing products of the proopiomelanocortin (POMC) gene (e.g., (3-endorphin, adrenocorticotropic hormone) make direct synaptic contacts with GnRH-containing neurons, and are found in the Arc, Read More

Leptin’s Actions on the Reproductive Axis: MECHANISMS OF LEPTIN’S ACTIONS ON REPRODUCTION(3)

Although distribution of Ob-R in the brain varies among those species studied thus far (for discussion see ), all species to date express Ob-R mRNA in the arcuate (Arc) and ventromedial nuclei (VMN) of the hypothalamus (Fig. 2A)—two areasacknowledgedtoinfluencebothfeeding and Read More

Leptin’s Actions on the Reproductive Axis: LEPTIN AND THE ONSET OF PUBERTY(4)

Is leptin the primary signal to awaken the reproductive system at puberty? The ability of exogenous leptin to initiate puberty prematurely would seem to strengthen support for the ‘‘critical body fat’’ hypothesis of sexual development. Two studies demonstrate an advancement Read More

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