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Dose-Response Relationship and Reproducibility of the Fall in Exhaled Nitric Oxide After Inhaled Beclomethasone Dipropionate Therapy in Asthma Patients: ResultsВ

Study B: Reproducibility of the Fall in Feno
Twelve subjects were enrolled in this study. Three subjects failed to return to baseline Feno by 6 weeks in period 3 and were withdrawn from the study. The results below refer to the nine subjects who completed the study.
Changes in Feno: The fall in Feno started 2 to 3 days after the active treatment (Fig 4). For Feno, both prebronchodilator and postbronchodilator, significant mean reductions were observed from period 1 to period 2, and from period 3 to period 4. No significant differences were found in mean Feno between period 1 and period 3, confirming the adequacy of the washout period, or between period 2 and period 4, indicating a reproducible effect of iBDP. The p value for the test comparing the mean fall in Feno from period 1 to period 2 with that from period 3 to period 4 was not significant for prebron-chodilator or postbronchodilator Feno (p = 0.470 and p = 0.385, respectively). This indicates that the effect on Feno of the two periods of iBDP treatment was reproducible (Fig 5). Excluding subject 4, who had particularly high Feno values, did not change any statistical outcomes. my canadian pharmacy

Change in FEV1 and FVC: FEV1 progressively increased from period 1 to period 4; unlike Feno, FEV1 did not fall on steroid withdrawal (Table 2). For FEV1, both prebronchodilator and postbron-chodilator, there were significant differences between the means values for period 1 and period 2 and for period 1 and period 3. No other significant differences were found between any periods for prebronchodilator or postbronchodilator FEV1. No significant differences were found between any periods for FVC prebronchodilator or postbronchodilator, nor were there significant differences in the mean changes from period 1 to period 2 and from period 3 to period 4.

Fig4

Figure 4. Reproducibility study: the changes in Feno (mean ± SD) in period 1 to period 4.

Fig5

Figure 5. Reproducibility study: the change in the mean of last two Feno measurements in each period for each subject for period 1 to period 4.