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Effect of high dose inhaled acetic acid on airway responsiveness in Fischer rats: DISCUSSION (4)

Reactive airways dysfunction syndrome

The present study indicates that induction of airway narrowing following high level inhaled irritant exposure is not sufficient to induce AHR and RADS in Fischer rats and suggests that additional factors play a role in this condition. There may be genetic factors, and a different strain of rats may demonstrate a different response, as suggested by the report of chlorine-induced hyper-responsiveness in Sprague-Dawley rats. Furthermore, differences in delivery method and tissue solubility of the irritant may also account for the different response. Alternatively, the exposure conditions in this study may not have induced a sufficient insult to the airways. A longer exposure or an exposure concentration closer to the lethal concentration may be needed to induce RADS in this model. In addition to the need for an animal model of RADS, there is a need for cross-sectional and prospective studies in the workplaces with moderate respiratory irritant exposures to clarify further the prevalence and incidence of AHR compared with workplaces without irritant exposures. In addition, the investigation of spill events may further define the dose-response relationship. levitra super active plus

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