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Helicobacter pylori anti-CagA antibodies: DISCUSSION Part 1

DISCUSSIONIn this study, the prevalence of H pylori in gastric biopsies of symptomatic subjects was determined by CLO, culture and histology. If one test was positive, patients were considered to be infected. Others have reported using a similar approach. In comparison with the biopsy-based tests, serology proved to be useful for the detection of H pylori infection. A review of the overall performance of the commercially available serology kits that measure IgG antibodies showed that serology is an accurate method of diagnosing H pylori in patients. Comparison between serology and the combination of CLO, histology and culture revealed 94% sensitivity and 88% specificity. Compared with the biopsy-based tests, ELISA was 89% sensitive and 100% specific in detecting H pylori infection in symptomatic subjects. These results were in agreement with those of an earlier study.

H pylori is associated with several gastroduodenal diseases such as gastritis, gastric ulcer, duodenal ulcer, gastric adenocarcinoma and mucosa-associated lymphoid tissue (MALT) lymphoma. CagA has been associated with the development of peptic ulcer disease and gastric cancer. It is expressed in approximately 60% of the isolates and the protein is highly immunogenic, while vacA gene, although present in nearly all strains, is expressed in only 50% of the isolates.

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