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Nonasthmatic chronic cough: DISCUSSION (2)

They found an increase in mononuclear cells and epithelial cell damage without eosinophilia or neutrophilia. Also, MacGarvey et al, examining the bronchoalveolar lavage fluid of 28 patients with nonasthmatic nonproductive cough due to postnasal syndrome, gastroesophageal reflux or of unknown cause, reported a significant increase in both eosinophils and mast cells. These results, therefore, differ from those in the present study, presumably due to differences in subject selection or in the airway compartments studied. Sputum neutrophilia in the present study was associated with elevated sputum IL-8 levels. This is not surprising because IL-8 is a neutrophil chemoattractant. The generally low levels of fluid phase ECP are in keeping with the absence of eosinophilia, although some patients had a raised ECP, which has also been reported without eosinophilia in chronic airflow limitation and natural colds. A sputum neutrophilia also occurs in smokers with or without chronic airflow limitation, with viral infections, and with exposure to endotoxin or ozone. Neutrophilia is, therefore, quite a nonspecific response, and its cause in the present study is unclear. levitra super active plus

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