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Thrombin, Inflammation, and Cardiovascular Disease: Atherothrombosis

While it remains unproven whether any of these mechanisms are actually at play in situ, given all the available data it seems likely that higher fibrinogen may well not only reflect the low-grade inflammation caused by the atherothrombosis, but also Read More

Thrombin, Inflammation, and Cardiovascular Disease: CVD risk

To support this position, studies of the plasma levels of prothrombin (a key procoagulant protein, but not an inflammation-sensitive protein) and/or the prothrombin G20210A genotype associated with plasma levels, generally have been null for CVD risk in most cases while Read More

Thrombin, Inflammation, and Cardiovascular Disease: Atherosclerosis, Thrombosis, and Inflammation

There Is a Complex Interplay Among Atherosclerosis, Thrombosis, and Inflammation Atherosclerotic coronary heart disease commonly manifests itself clinically via a thrombotic event: so-called “atherothrombosis,” especially in younger men. As mentioned above, this has been clearly understood only since the early Read More

Thrombin, Inflammation, and Cardiovascular Disease: Thrombotic disease

Overall, a meta-analysis demonstrated moderate risk prediction for d-dimer. The most likely interpretation of these data are that the degree of atherosclerosis and vascular damage causes changes in coagulation status, not vice versa; ie, it does not appear that a Read More

Thrombin, Inflammation, and Cardiovascular Disease: MI and CVD death

Is There a Hypercoagulable State That Predisposes to CVD? Meade and colleagues at the Northwick Park Heart Study produced pioneering research into the molecular epidemiology of coagulation and fibrinolysis, which suggested that a preexisting hypercoagulable state might be present in Read More

Thrombin, Inflammation, and Cardiovascular Disease: Thrombin-activated fibrinolysis inhibitor

Thrombin is also responsible for the activation of a newly discovered major thrombosis regulator, thrombin-activated fibrinolysis inhibitor, also discussed in more detail by Dr. Nesheim elsewhere in this supplement. Thrombin-activated fibrinolysis inhibitor appears to play a major role in down-regulating Read More

Thrombin, Inflammation, and Cardiovascular Disease

Atherosclerosis and resulting clinical cardiovascular disease (CVD) are complex pathophysiologic processes involving a large number of genes and gene products in complicated interactions with a variety of environmental influences. An enormous body of research over the last 20 years has Read More

Comparison of Function of Commercially Available Pleural Drainage Units and Catheters: Conclusion

All other PDU models demonstrated significant pressure accuracy error differences between the two external suction settings (manufacturer-suggested wall suction setting vs full wall suction) in the negative direction (delivering more negative pressure than the PDU test value). The least accurate Read More

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