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Identification of Spontaneous Feline Idiopathic Pulmonary Fibrosis: UIP changes

Cats with IPF acquire lung histopathology similar to human IPF. Previous to the 2000 statement designating UIP as the pathologic manifestation of IPF, acute interstitial pneumonia, desquamative interstitial pneumonia, and NSIP were also considered variations of IPF. These other pulmonary Read More

Identification of Spontaneous Feline Idiopathic Pulmonary Fibrosis: Human IPF

This study describes spontaneous feline IPF, a newly identified chronic lung disease of domestic cats that shares critical features with human IPF. The important gross pathology, histopa-thology, cell differentiation markers, and ultrastruc-tural features are compared to the well-described features of Read More

Identification of Spontaneous Feline Idiopathic Pulmonary Fibrosis: Discussion

Ultrastructure: In the toluidine blue-stained, plastic-embedded lung prepared for electron microscopy, the interstitium of the pulmonary parenchyma was markedly thickened with abundant collagen. In the areas of type II pneumocyte hyperplasia and differentiation, the individual pneumocytes contained many cytoplasmic, variably Read More

Identification of Spontaneous Feline Idiopathic Pulmonary Fibrosis: Lung

Fibroblast foci, small foci of ongoing mesenchymal cell proliferation with fibroblasts/myofibroblasts and collagen, similar to the foci seen in UIP of humans were observed at the periphery of the honeycomb lung (Fig 3, top left, A [human], and top right, Read More

Identification of Spontaneous Feline Idiopathic Pulmonary Fibrosis: Necropsy Findings

Grossly, the distribution of lesions involved large regions of the lungs. The pleural surface of the lungs was often irregular and cobblestoned in appearance (Fig 1, top, A). The areas of fibrosis and remodeling formed plaque-like depositions that were discrete Read More

Identification of Spontaneous Feline Idiopathic Pulmonary Fibrosis: Immunohistochemistry

Electron Microscopy: Tissues from three affected cats were prepared for electron microscopy. The samples were rinsed in 0.1 mol/L phosphate buffer and placed in osmium tetroxide (Electron Microscopy Sciences; Fort Washington, PA) for 3 h. The tissues were then rerinsed Read More

Identification of Spontaneous Feline Idiopathic Pulmonary Fibrosis: Materials and Methods

We report herein a novel spontaneous chronic, progressive respiratory disease in domestic cats with the morphologic features of UIP; these features include the temporal heterogeneity, persistent, progressive proliferation of myofibroblasts/fibroblasts, and an association between IPF and the development of primary Read More

Identification of Spontaneous Feline Idiopathic Pulmonary Fibrosis: IPF

Animal models currently used to study IPF do not appropriately mimic the morphologic changes of IPF. As stated in the National Heart, Lung, and Blood Institute workshop summary,2 persistent progressive fibrosis with evidence of temporal heterogeneity is a hallmark of Read More

Identification of Spontaneous Feline Idiopathic Pulmonary Fibrosis

Idiopathic pulmonary fibrosis (IPF), also known as cryptogenic fibrosing alveolitis, is a poorly understood respiratory disease of humans. Affecting approximately 11 male and 8 female patients, respectively, per 100,000 individuals per year, it is one of the more prevalent interstitial Read More

Chemoprevention of Lung Cancer in Transgenic Mice: Use of Transgenic Mouse Model in Chemoprevention Studies

We examined the effects of two potential agents on the development of adenomas/adenocarcinomas in these mice. The two classes of agents examined were budes-onide’ and the FTI inhibitor L778,123. The former is a glucocorticoid that presumably interacts with the glucocorticoid Read More

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