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Chemoprevention of Lung Cancer in Transgenic Mice: Lung tumors

The incidence of lung tumors in all four groups of treated mice was 100%. p53+/-Ink4a/Arf+/+, and p53+/-Ink4a/ Arf+/- mice carrying a mutant p53 transgene (Val135) with or without Ink4a/Arf heterozygous deletion had a higher number of lung tumors (an average Read More

Chemoprevention of Lung Cancer in Transgenic Mice: Transgenic Mouse Model for Lung Adenocarcinomas

Although the A/J mouse lung adenoma model is valuable because of similar histology to a subtype of human adenocarcinoma, there are some features yet to be desired in order to make this model better. For example, the progression of lung Read More

Chemoprevention of Lung Cancer in Transgenic Mice: Use of A/J Mice in Chemoprevention Studies

The A/J mouse lung model of chemical carcinogenesis has been the most frequently employed murine model both for testing for potential chemical carcinogens and to screen for agents that prevent carcinogenesis (chemopre-ventive agents). The model has been shown to respond Read More

Chemoprevention of Lung Cancer in Transgenic Mice

Lung cancer is the leading cause of cancer deaths in men and women in the United States. Epidemiologic and laboratory animal model studies have demonstrated that smoking and environmental exposure to carcinogens are closely linked to increased lung cancer risk. Read More

Risk and Severity of COPD Is Associated With the Group-Specific Component of Serum Globulin 1F Allele: Conclusion

There are several limitations in our study. First, the age and smoking history in pack-years of the control group were not exactly equivalent to the COPD patient group. Considering that some sub jects in the control group might subsequently acquire Read More

Risk and Severity of COPD Is Associated With the Group-Specific Component of Serum Globulin 1F Allele: FEV1/FVC

Previous studies have shown that LAA% and sCLA correlated well with FEV1 percentage predicted and FEV1/FVC. In HRCT examinations, patients with Gc*1F allele had a higher LAA%, lower mean CT score, and larger sCLA than patients without the allele, whereas Read More

Risk and Severity of COPD Is Associated With the Group-Specific Component of Serum Globulin 1F Allele:

They concluded that the reason was due to the insufficient number of subjects needed to verify the hypothesis that Gc*1F homozygotes had an increased risk. These studies were based on white populations in which the frequencies of the three alleles Read More

Risk and Severity of COPD Is Associated With the Group-Specific Component of Serum Globulin 1F Allele: Discussion

Simple linear regression analysis was used for studying correlations between LAA% and mean CT score. Mean CT score was linearly correlated with LAA% (R2 = 0.97, p < 0.001), with a simple linear regression model as follows: mean CT score Read More

Risk and Severity of COPD Is Associated With the Group-Specific Component of Serum Globulin 1F Allele: dFEV1

Follow-up pulmonary function data for calculating dFEV1 was available in 86 of the 103 patients with COPD, and 21 of the 88 smoker control subjects, There was no significant difference in age, smoking history, the baseline FEV1 percentage predicted, and Read More

Risk and Severity of COPD Is Associated With the Group-Specific Component of Serum Globulin 1F Allele: Pulmonary Function Testing

Pulmonary function tests were performed at the initial visit, and at each of the follow-up visits. The initial test values were used as the baseline data. When follow-up data were available > 1 year after the initial test, dFEV1 was Read More

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