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Risk and Severity of COPD Is Associated With the Group-Specific Component of Serum Globulin 1F Allele: Statistical Analysis

To test Gc-globulin phenotypic variance between patients with COPD and healthy smokers, and to compare the frequency of individuals over or under the threshold (dFEV1 > 90 mL/yr, LAA% > 60%, or mean CT score < — 940 HU) in Read More

Risk and Severity of COPD Is Associated With the Group-Specific Component of Serum Globulin 1F Allele: Genotyping

DNA for genotyping was extracted from blood using standard phenolchloroform method. To detect point mutations in exon XI (Glu/Asp 416 and Thr/Lys 420) of the Gc-globulin gene, polymerase chain reaction (PCR) was performed followed by restriction fragment-length polymorphism analysis. To Read More

Risk and Severity of COPD Is Associated With the Group-Specific Component of Serum Globulin 1F Allele: Materials and Methods

We also considered it important to test the contribution of Gc-globulin genotypes to the disease progression or severity in patients with COPD because, to our knowledge, this has not yet been investigated. The annual decline of FEV1 (dFEV1) is often Read More

Risk and Severity of COPD Is Associated With the Group-Specific Component of Serum Globulin 1F Allele

Although the most critical factor for acquiring COPD is cigarette smoking, only 15 to 20% of chronic smokers get this disease. Several epidemiologic studies have suggested familial clustering of the disease. This suggests that the genetic factors are likely to Read More

Comparison of Continuous and Discrete Measurements of Dyspnea During Exercise in Patients With COPD and Normal Subjects: Ekman Fraction

For all sensory modalities, Weber’s law states that the physical change in the size of a JND must be increased by a constant fraction of its original or background value to produce a perceived change in sensory experience. Whereas the Read More

Comparison of Continuous and Discrete Measurements of Dyspnea During Exercise in Patients With COPD and Normal Subjects: VE-dyspnea

However, the x-intercept for the VE-dyspnea relationship was significantly higher in patients with COPD compared with healthy subjects. These findings are consistent with previous observations that VE is higher at similar exercise intensities in patients with COPD compared to normal Read More

Comparison of Continuous and Discrete Measurements of Dyspnea During Exercise in Patients With COPD and Normal Subjects: Healthy Subjects

The continuous method also permits calculation of an absolute threshold corresponding to the onset of breathlessness in a manner similar to standard procedures followed throughout other areas of sensory psychophysics. In other words, there are no statistical assumptions required in Read More

Comparison of Continuous and Discrete Measurements of Dyspnea During Exercise in Patients With COPD and Normal Subjects: Statistical Analysis Considerations

Both linear, and power2, function equations have been used to summarize the relationships between physiologic variables during exercise and the perceptual response of dyspnea. In simple terms, both approaches involve the matching of one continuum to another continuum. In 1992, Read More

Comparison of Continuous and Discrete Measurements of Dyspnea During Exercise in Patients With COPD and Normal Subjects: Discussion

Table 3 presents summary data for the parameters of the linear regression analyses and absolute thresholds for the independent variables of power production, V02, and VE, respectively. There were no significant differences for the slopes and intercepts for the three Read More

Comparison of Continuous and Discrete Measurements of Dyspnea During Exercise in Patients With COPD and Normal Subjects: Test-Retest Reliability

The best-fitting linear equation is shown for each relationship. For each group, there were high Pearson correlation coefficients for power production (r = 0.96 to 0.98), Vo2 (r = 0.95 to 0.96), and Ve (r = 0.95 to 0.97) and Read More

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