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Spectroscopic approach to capillary-alveolar membrane damage: RESULTS AND DISCUSSION (3)

IR pathology of pulmonary HES leakage: A demonstration of the pulmonary leakage in an ARDS patient was perfo-med by IR microscopy using autopsy material from a 49-year-old male who presented to the trauma service at the Health Sciences Centre, Winnipeg, Manitoba. The patient was involved in a motor vehicle accident in which a tractor-trailer rolled over him, and he sustained a fractured pelvis with a significant retroperitoneal hematoma. Over the next 48 h, the patient developed clinical signs of ALI/ARDS. He received antibiotics, ventilatory support and continuous venovenous hemodialysis. PENTASPAN was administered for oncotic manipulation. The IR spectra of the bronchial washings, collected 3 h after infusion of PENTASPAN, contained HES.

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