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Tag: Airway inflammation

Nonasthmatic chronic cough: DISCUSSION (4)

This is the first randomized, controlled trial to examine the effects of treatment with inhaled steroid on cough discomfort as well as inflammatory indexes. Budesonide 800 |ig daily for two or four weeks had no effect. The results emphasize the Read More

Nonasthmatic chronic cough: DISCUSSION (3)

An unexpected finding was elevated levels of sputum fibrinogen and albumin that we attribute to microvascular leakage. This observation is in line with bronchial biopsies of children with chronic cough showing marked increase in the percentage of area of intercellular Read More

Nonasthmatic chronic cough: DISCUSSION (2)

They found an increase in mononuclear cells and epithelial cell damage without eosinophilia or neutrophilia. Also, MacGarvey et al, examining the bronchoalveolar lavage fluid of 28 patients with nonasthmatic nonproductive cough due to postnasal syndrome, gastroesophageal reflux or of unknown Read More

Nonasthmatic chronic cough: DISCUSSION (1)

This study demonstrates that chronic cough without asthma or known cause is associated with lower airway inflammation. The inflammatory response was noneosino-philic in all patients and neutrophilic in the majority, and this was accompanied by increased microvascular leakage (as measured Read More

Nonasthmatic chronic cough: RESULTS (3)

Effect of treatment on cough: Cough discomfort before and after two weeks of treatment with placebo or budesonide was examined. The severity of cough discomfort before treatment did not differ between the treatment groups (Table 1) nor between patients with Read More

Nonasthmatic chronic cough: RESULTS (2)

Sputum appearance, cell viability, total and differential cell counts, and the fluid phase measurements of the 32 patients who produced sputum before treatment (Table 2) were examined. In 19 (59%) patients, the proportion and absolute number of neutrophils were above Read More

Nonasthmatic chronic cough: RESULTS (1)

Randomization and withdrawals: Fifty patients were randomized to one or other study treatment (Figure 1). Twenty-five patients received budesonide and 25 placebo. Two patients (one placebo, one budesonide) were found ineligible after randomization, one because of an abnormal chest radiograph Read More

Nonasthmatic chronic cough: PATIENTS AND METHODS (5)

The limits of detection for ECP, fibrinogen, IL-8 and substance P were 2.0 mg/mL, 0.79 mg/L, 25.6 pg/mL and 0.62 pg/mL, respectively. Data analysis: Clinical variables were summarized by means and 95% CI, except for PC20 data, which were log Read More

Nonasthmatic chronic cough: PATIENTS AND METHODS (4)

Sputum examination: Sputum was selected from the expectorate and processed as described elsewhere. The success of the selection was confirmed by a proportion of squamous epithelial cells of 5% or less. The concentration of ECP (|ig/L) in the thawed supernatant Read More

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