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Tag: asthma

Canadian Neighbor Pharmacy: Chronic Airflow Limitation

While the classic diseases of dusty occupations, in particular the pneumoconioses, have not yet disappeared, they may be on the decline. In contrast, mortality rates due to the chronic nonmalignant pulmonary conditions including those characterized by airflow limitation are increasing Read More

Association of Asthma Severity and Bronchial Hyperresponsiveness With a Polymorphism: Asthmatic airways

The first possible shortcoming of this study was that the methacholine challenge was performed in only 45 of 88 patients, which would have resulted in a selection bias. The most important reason for not performing the methacholine challenge concerned the Read More

Association of Asthma Severity and Bronchial Hyperresponsiveness With a Polymorphism: Discussion

In this study, the CTLA-4 promoter ( — 318 C/T) polymorphism was found to be associated with asthma severity, but not with asthma, atopy, or bronchial hyperresponsiveness. The CTLA-4 exon 1 (+ 49 A/G) polymorphism was shown to be associated Read More

Association of Asthma Severity and Bronchial Hyperresponsiveness With a Polymorphism: Polymorphism

The distributions of genotypic frequencies were significantly different for the mild-to-moderate group and the severe group. In particular, the frequency of the T allele was 7.4% in the mild-to-moderate group and 20.4% in the severe group, and the association between Read More

Association of Asthma Severity and Bronchial Hyperresponsiveness With a Polymorphism: Genotyping of CTLA-4 Gene

Classification of asthma severity was based on history, symptoms, clinical features, medication need, FEV1, and PEF according to the 1997 Expert Panel Report 2. Asthma severity was classified into mild intermittent, mild persistent, moderate persistent, and severe persistent. The investigator Read More

Association of Asthma Severity and Bronchial Hyperresponsiveness With a Polymorphism: Clinical Assessment

All control subjects were nonsmokers and had normal findings on chest radiographs, normal airway reactivity, and normal pulmonary function test results. Moreover, they had experienced no current respiratory symptoms, were nonatopic, and had experienced no respiratory infections within the previous Read More

Association of Asthma Severity and Bronchial Hyperresponsiveness With a Polymorphism: Materials and Methods

Polymorphisms of the CTLA-4 gene, located on chromosome 2q33, could thus have effects on immune response. The following three CTLA-4 gene polymorphisms are known: a microsatellite (AT)n marker at position 642 of the 3′-untranslated region of exon 4; a single-nucleotide Read More

Association of Asthma Severity and Bronchial Hyperresponsiveness With a Polymorphism

Bronchial asthma is characterized by the infiltration of inflammatory cells into the airway submucosa. While the precise mechanisms by which inflammatory cells are recruited into the lungs are not fully understood, increasingly available evidence suggests that the activation of antigen-specific Read More

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