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Tag: pleura

Systemic Inflammatory Effects During the Acute Phase of Experimental Pleurodesis in Rabbits: Conclusion

Although there have been reports of adverse systemic effects in humans when TL has been administered intrapleurally, there have been limited reports on the systemic effects after the intrapleural administration of this low dose of SN. One study (an abstract) Read More

Systemic Inflammatory Effects During the Acute Phase of Experimental Pleurodesis in Rabbits: LDH

It has been hypothesized that this systemic dissemination of TL is more likely if TL with a smaller mean particle size is used.- TL particles have been shown to vary markedly in median particle size.” It is hypothesized that small Read More

Systemic Inflammatory Effects During the Acute Phase of Experimental Pleurodesis in Rabbits: Discussion

SN also induced a systemic response, with increases in serum LDH, IL-8, and VEGF levels. The serum LDH level increased 6 h after injection, and decreased after 24 and 48 h. The serum levels of IL-8 were higher than those Read More

Systemic Inflammatory Effects During the Acute Phase of Experimental Pleurodesis in Rabbits: IL-8

Pleural Fluid Volume: The pleural fluid volume was significantly greater after the intrapleural injection of SN than it was after the intrapleural injection of TL at each time point (Table 1). The amount of pleural fluid tended to increase with Read More

Systemic Inflammatory Effects During the Acute Phase of Experimental Pleurodesis in Rabbits: Pleural Fluid

LDH: The intrapleural injection of SN, but not TL or saline solution, led to a short-term increase in serum LDH levels. The mean serum LDH level was significantly higher 6 h after the injection of SN (540 ± 215 IU/L) Read More

Systemic Inflammatory Effects During the Acute Phase of Experimental Pleurodesis in Rabbits: Cytokines Analysis

IL-8 (OptEIA, rabbit IL-8 set; Pharmingen; San Diego, CA) and VEGF (R&D Systems; Minneapolis, MN) were measured by enzyme-linked immunosorbent assay according to the manufacturers’ directions. Quantification of IL-8 and VEGF was done by comparison of the optical density in Read More

Systemic Inflammatory Effects During the Acute Phase of Experimental Pleurodesis in Rabbits: Reagents

The animals were killed with a lethal injection of pentobarbital (USP Pharmacy). Immediately before the pentobarbital injection, a blood sample from each animal was collected for comparison with normal blood parameters from noninjected rabbits. After death, the animals were exsanguinated Read More

Systemic Inflammatory Effects During the Acute Phase of Experimental Pleurodesis in Rabbits: Pleural Injection

SN was one of the first agents used for pleurodesis in concentrations varying from 1 to 10% and had a success rate of 75 to 90%. In a rabbit model with normal pleura, the intrapleural injection of 0.5% SN produced Read More

Systemic Inflammatory Effects During the Acute Phase of Experimental Pleurodesis in Rabbits

Pleurodesis is routinely used for the treatment of recurrent malignant pleural effusions. Many agents have been used to produce a pleural symphysis, including silver nitrate (SN), quinacrine, tetracycline and its derivatives doxycycline and minocycline, bleomycin, Corynebacterium parvum, and talc (TL), Read More