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Tag: Reactive airways dysfunction syndrome

Effect of high dose inhaled acetic acid on airway responsiveness in Fischer rats: DISCUSSION (4)

The present study indicates that induction of airway narrowing following high level inhaled irritant exposure is not sufficient to induce AHR and RADS in Fischer rats and suggests that additional factors play a role in this condition. There may be Read More

Effect of high dose inhaled acetic acid on airway responsiveness in Fischer rats: DISCUSSION (3)

While it is clear that postchemical injury respiratory symptoms associated with AHR do occur, it is still unclear whether they always represent a de novo irritant-induced asthmatic state. Clinical irritant-induced asthma is probably a heterogeneous entity, including cases of previously Read More

Effect of high dose inhaled acetic acid on airway responsiveness in Fischer rats: DISCUSSION (2)

The great majority of subjects exposed to irritant spillsdo not develop RADS. Most symptomatic individuals recover within a few days. Early symptoms are often related to upper airway irritation, and are more common in smokers and asthmatics. Persistent respiratory symptoms Read More

Effect of high dose inhaled acetic acid on airway responsiveness in Fischer rats: DISCUSSION (1)

RESULTS Immediate postexposure response: RL and EL increased significantly in the study group (n=11). Apart from a transient, postexposure increase in RL and EL, we did not demonstrate a significant change in lung mechanics or airway responsiveness, measured 24 h Read More

Effect of high dose inhaled acetic acid on airway responsiveness in Fischer rats: ANIMALS AND METHODS (4)

Acetic acid exposure: Animals were exposed to acetic acid by having them inhale a nebulized solution of acetic acid for 2 mins, using the same delivery method. The nebulizer was changed, and the plastic box was thoroughly flushed immediately following Read More

Effect of high dose inhaled acetic acid on airway responsiveness in Fischer rats: ANIMALS AND METHODS (3)

Aerosol generation: Aerosols were generated using a Hudson nebulizer (Model 1700, Hudson Oxygen Therapy, California) containing 3 mL of solution, which was driven by compressed air source at an airflow of 6 L/min (nebulizer output 0.17 mL/min). The nebulizer was Read More

Effect of high dose inhaled acetic acid on airway responsiveness in Fischer rats: ANIMALS AND METHODS (2)

The frequency response of the box was flat up to 10 Hz. A Fleisch number 0 pneumotachograph (PTG) (Fleisch, Lauzanne, Switzerland) coupled to a differential pressure transducer (MP-45; ±2 cm H2O, Validyne Corporation, California) was attached to the other end Read More

Effect of high dose inhaled acetic acid on airway responsiveness in Fischer rats: ANIMALS AND METHODS (1)

Animal subject approval: Institutional approval was obtained for the use of the animals in this study. Animals, anesthesia and preparation: Fourteen male Fischer rats eight- to 10-weeks of age and weighing 130 to 330 g (Charles River) were housed in Read More

Effect of high dose inhaled acetic acid on airway responsiveness in Fischer rats (3)

Prospective clinical studies have not clearly documented de novo induction of long standing AHR by moderate irritant exposures. A report of workers exposed to calcium oxide dust did not find an increase in new-onset buy asthma inhalers. However, recurrent exposures Read More

Effect of high dose inhaled acetic acid on airway responsiveness in Fischer rats (2)

Diagnosis of irritant-induced asthmais based on the exposure history, timing of onset of symptoms, demonstration of AHR and lack of previously documented respiratory disease. No specific investigations confirm the diagnosis; the diagnosis is tenuous and cannot be distinguished from the Read More

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