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Tag: respiratory bronchiolitis-associated interstitial lung disease

The Overlap Between Respiratory Bronchiolitis and Desquamative Interstitial Pneumonia: Conclusion

Our study suggests that in some individuals with PLCH, extensive RB/ DIP-like changes may be the lesion responsible for the majority of physiologic and clinical abnormalities, rather than the lesions of PLCH. Irrespective of how one defines the final pathologic Read More

The Overlap Between Respiratory Bronchiolitis and Desquamative Interstitial Pneumonia: PLCH biopsy specimens

Whereas RB is an extremely common lesion that refers to the universal inflammatory reaction found in the respiratory bronchioles of cigarette smokers, RB-ILD is an uncommon ILD that occurs in a small proportion of smokers. In analogy to DIP, the Read More

The Overlap Between Respiratory Bronchiolitis and Desquamative Interstitial Pneumonia: Discussion

No correlation was found between the degree of RB/DIP-like changes and pulmonary function parameters, including TLC (r = — 0.22, p = 0.45), Dlco (r = — 0.42, p = 0.13), or FEV1 (r = 0.11, p = 0.71). Although Read More

The Overlap Between Respiratory Bronchiolitis and Desquamative Interstitial Pneumonia: Radiographic

Cystic change was identified as the sole HRCT abnormality in three cases. Ground-glass attenuation was detected on HRCT in three patients (Table 2). Emphysema was detected in two cases on HRCT (14%). Mild sub-carinal and pretracheal adenopathy (1 to 2 Read More

The Overlap Between Respiratory Bronchiolitis and Desquamative Interstitial Pneumonia: Clinical and Radiographic Characteristics

The second patient (patient 2 in Tables 1, 2) was a 48-year-old white man with a 30-pack-year smoking history referred for evaluation of progressive dyspnea. Although claiming to have quit smoking several months prior to evaluation, arterial blood gas analysis Read More

The Overlap Between Respiratory Bronchiolitis and Desquamative Interstitial Pneumonia: Results Summary of the Two Index Cases

Correlations between the extent of RB/DIP-like changes (0 to 100% involvement of biopsy) and total pack-years smoked was performed using linear regression analysis and the Pearson correlation coefficient. Similarly, correlations between the extent of RB/DIP-like changes and pulmonary function variables Read More

The Overlap Between Respiratory Bronchiolitis and Desquamative Interstitial Pneumonia: HRCT

When present, the distribution of the abnormalities such as adenopathy and emphysema was recorded. Surgical lung biopsy specimens were reviewed by a pathologist (T.V.C.) blinded to the findings on HRCT. Accumulation of pigmented macrophages in airspaces and around respiratory bronchioles Read More

The Overlap Between Respiratory Bronchiolitis and Desquamative Interstitial Pneumonia: Materials and Methods

The medical record of two index patients with PLCH associated with marked RB/DIP-like changes on biopsy were reviewed and summarized. To further characterize the relationship between RB/DIP and PLCH, we searched the Mayo Clinic database and identified 10 additional cases Read More

The Overlap Between Respiratory Bronchiolitis and Desquamative Interstitial Pneumonia

Pulmonary Langerhans cell histiocytosis (PLCH) is an uncommon interstitial lung disorder that occurs almost exclusively in smokers. Cigarette smoking has also been implicated in the development of respiratory bronchiolitis (RB)-associated interstitial lung disease (ILD) [RB-ILD] and desquamative interstitial pneumonia (DIP), Read More